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- Via Italian ports: Venice, Ancona, Bari, Brindisi to Igoumenitsa port, then drive 2 hours about to Lefkada direct.
- From Thessaloniki: via Egnatia motorway to Ioannina then drive direct to Lefkada, total 4,5 hours.
- From north Greece: via Egnatia motorway to Ioannina then drive 2.5 hour to Lefkada direct.
- From Athens or Patras: via Rio-Antirio (big bridge) – Amfilochia – Lefkada: 3.5 hours from Patras and 5 hours from Athens drive to Lefkada direct.
- From Aktio-Preveza Airport (PVK): 20km drive to Lefkada direct (35 minutes drive).
- From Ioannina airport via Athens: drive 2.5 hours to Lefkada direct
- From Corfu island: Ferryboat to Igoumennitsa port and then drive 2 hours to Lefkada direct.
- From Peloponisos Araxos Airport: via Rio-Antirio (big bridge) 4 hours drive to Lefkada direct.
- From most of the Europian cities that they have charter flights to Aktio-Preveza Airport (PVK) and then drive 20km to Lefkada direct.
- Balcan countries by car via Egnatia motorway to Ioannina, then drive direct to Lefkada
